Novel proteins with enhanced functionality and methods of making novel proteins using circular permutation

作者: Stefan Lutz , Zhen Qian

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摘要: The present disclosure is relates to novel proteins and peptides having and/or enhanced functions behaviors with respect a native protein or peptide, methods of making the using techniques circular permutation engineering.

参考文章(15)
Marc Ostermeier, Stephen J. Benkovic, Evolution of protein function by Domain swapping Advances in Protein Chemistry. ,vol. 55, pp. 29- 77 ,(2001) , 10.1016/S0065-3233(01)55002-0
Roger Y. Tsien, Geoffrey A. Baird, Fluorescent protein indicators ,(2000)
Robert J. Kreitman, Raj K. Puri, Ira Pastan, Circularly permuted ligands and circularly permuted chimeric molecules ,(1995)
Michael Kriegler, Francis P. McCormick, Retroviral vectors expressing cytokines ,(1995)
Ira Pastan, Raj K. Puri, Waldemar Debinski, Nicholas Obiri, IL-13 receptor specific chimeric proteins and uses thereof ,(1996)
Stefan Lutz, Engineering lipase B from Candida antarctica Tetrahedron-asymmetry. ,vol. 15, pp. 2743- 2748 ,(2004) , 10.1016/J.TETASY.2004.06.031
Zhen Qian, Stefan Lutz, Improving the catalytic activity of Candida antarctica lipase B by circular permutation. Journal of the American Chemical Society. ,vol. 127, pp. 13466- 13467 ,(2005) , 10.1021/JA053932H
R.A. Horlick, H.J. George, G.M. Cooke, R.J. Tritch, R.C. Newton, A. Dwivedi, M. Lischwe, F.R. Salemme, P.C. Weber, R. Horuk, Permuteins of interleukin 1β—a simplified approach for the construction of permutated proteins having new termini Protein Engineering. ,vol. 5, pp. 427- 431 ,(1992) , 10.1093/PROTEIN/5.5.427
Roger Y. Tsien, Geoffrey Baird, Circularly permuted fluorescent protein indicators ,(2001)