Methylome-wide Sequencing Detects DNA Hypermethylation Distinguishing Indolent from Aggressive Prostate Cancer

摘要: A critical need in understanding the biology of prostate cancer is characterizing molecular differences between indolent and aggressive cases. Because DNA methylation can capture regulatory state tumors, we analyzed differential patterns genome-wide among benign prostatic tissue low-grade high-grade found extensive, focal hypermethylation regions unique to disease. These occurred not only promoters genes but also gene bodies at intergenic that are enriched for DNA-protein binding sites. Integration with existing RNA-sequencing (RNA-seq) survival data revealed where correlates reduced expression associated poor outcome. Regions specific disease proximal distinct functions from shared by Our compendium changes reveals crucial distinctions cancer.