Cytologic features of triple-negative breast carcinoma.

摘要: BACKGROUND: Triple-negative breast cancer (TNBC) is distinct from other cancers, because the tumor cells lack estrogen and progesterone receptors (hormone receptors) also are negative for human epidermal growth factor receptor 2 (HER2). They comprise a heterogeneous group of tumors with various histologic features clinical behaviors. High-grade, invasive ductal carcinoma not otherwise specified most frequent type, substantial fraction TNBCs belongs to basal-like type. The purpose this study was determine whether some cytologic could predict triple phenotype carcinoma. METHODS: Fine-needle aspiration cytology samples 62 were compared 82 hormone receptor-positive, high-grade, carcinomas (HRBC) 33 receptor-negative, HER2 positive, (HER2BC) following cytomorphologic features: cellularity, necrosis, lymphocytes, syncytial clusters, tubular/ductal-like large bare nuclei, streaming within calcifications. Moreover, single cell features, such as cellular borders, cytoplasm, cytoplasmic vacuoles, nuclear pleomorphism, nucleoli, type chromatin pattern, evaluated. Descriptive analyses multivariate regression models performed compare TNBC, HRBC, HER2BC identify factors that associated type. RESULTS: TNBCs more likely have an abundant necrotic background, many ill defined borders than non-TNBCs. A tubular/ductal pattern observed only rarely in TNBCs. Multivariate logistic analysis indicated 90.8% probability identifying TNBC versus HRBC by variables: pleomorphism; whereas there 77.5% rather clusters. CONCLUSIONS: Although embrace tumors, study, they exhibited common can help distinguish them high-grade daily practice. Cancer (Cancer Cytopathol) 2012;. © 2012 American Society.