Control of cell motility during tissue invasion

摘要: Invasion of the surrounding tissue by tumor cells is a complex process and involves destruction active cell movement. Regulation motility complex. There are type-specific differences (for example, between fibroblasts epithelial cells) transformed their normal counterparts. Under circumstances, exist in as single cells. Reflecting this, migrate Epithelial sheets or threedimensional masses. migration groups moving together well movement individual For both cells, vitro requires substratum to which can adhere. Components extracellular matrix including fibronectin laminin provide suitable substrate. Differences elaboration fibronectin/laminin interaction with these motilityinducing molecules contribute motility. When interact (or other motility-supporting molecules), binding surface adhesion receptors initiates cascade signaling events that results organization for In also critical However, significant does not occur unless there soluble motility-stimulating factors (i.e. growth factors, chemokines complement components). While has been extensively studied simple two-dimensional three-dimensional assay systems, recent studies using intact organ culture have validated many observations resulting from systems.