Anti-cancer effects of Phyllanthus urinaria and relevant mechanisms.
作者： Rong-Chi Yang , Jong-Hwei S Pang , Sheng-Teng Huang
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摘要: Phyllanthus urinaria (P. urinaria), a widely used herbal medicine, has been reported to possess various biological activities. This report aimed characterize the whole P. plant, present anticancer effects of both in vivo and vitro, explore relevant mechanisms. The water extract not only significantly reduces cell viability cancer lines from different origins but also suppresses tumor development C57BL/6J mice after implantation Lewis lung carcinoma (LCC) cells. activity is mainly due induced apoptosis cells as demonstrated by DNA fragmentation increased caspase-3 through intrinsic extrinsic pathways. decrease with treatment might be partially associated down-regulation telomerase activation induction apoptotic process. In addition, exhibits anti-angiogenic that mediated, at least part, suppression matrix metalloproteinase 2 (MMP-2) secretion inhibition MMP-2 zinc chelation.
cabdirect.org参考文章(34)
Folkman J, The role of angiogenesis in tumor growth. Seminars in Cancer Biology. ,vol. 3, pp. 65- 71 ,(1992)
Tadakazu Kondo, Tomoko Matsuda, Masaro Tashima, Hisanori Umehara, Naochika Domae, Kazunao Yokoyama, Takashi Uchiyama, Toshiro Okazaki, Suppression of heat shock protein-70 by ceramide in heat shock-induced HL-60 cell apoptosis. Journal of Biological Chemistry. ,vol. 275, pp. 8872- 8879 ,(2000) , 10.1074/JBC.275.12.8872
Peter Carmeliet, Rakesh K. Jain, Angiogenesis in cancer and other diseases Nature. ,vol. 407, pp. 249- 257 ,(2000) , 10.1038/35025220
Garth Powis, David J. Moore, High-performance liquid chromatographic assay for the antitumor glycoside phyllanthoside and its stability in plasma of several species. Journal of Chromatography B: Biomedical Sciences and Applications. ,vol. 342, pp. 129- 134 ,(1985) , 10.1016/S0378-4347(00)84495-3
Moira Sauane, Zao-zhong Su, Rupesh Dash, Xiang Liu, James S. Norris, Devanand Sarkar, Seok-Geun Lee, Jeremy C. Allegood, Paul Dent, Sarah Spiegel, Paul B. Fisher, Ceramide Plays a Prominent Role in MDA-7/IL-24-Induced Cancer-Specific Apoptosis Journal of Cellular Physiology. ,vol. 222, pp. 546- 555 ,(2009) , 10.1002/JCP.21969
Douglas Hanahan, Judah Folkman, Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis Cell. ,vol. 86, pp. 353- 364 ,(1996) , 10.1016/S0092-8674(00)80108-7
Ran R. Liu, Timothy H. Murphy, Reversible cyclosporin A-sensitive mitochondrial depolarization occurs within minutes of stroke onset in mouse somatosensory cortex in vivo: a two-photon imaging study. Journal of Biological Chemistry. ,vol. 284, pp. 36109- 36117 ,(2009) , 10.1074/JBC.M109.055301
Sheng-Teng Huang, Rong-Chi Yang, Jong-Hwei S. Pang, Aqueous Extract of Phyllanthus urinaria Induces Apoptosis in Human Cancer Cells The American Journal of Chinese Medicine. ,vol. 32, pp. 175- 183 ,(2004) , 10.1142/S0192415X04001849
Begoña Cerdá, Francisco A. Tomás-Barberán, Juan Carlos Espín, Metabolism of antioxidant and chemopreventive ellagitannins from strawberries, raspberries, walnuts, and oak-aged wine in humans: identification of biomarkers and individual variability Journal of Agricultural and Food Chemistry. ,vol. 53, pp. 227- 235 ,(2005) , 10.1021/JF049144D
Heather A. Ross, Gordon J. McDougall, Derek Stewart, Antiproliferative activity is predominantly associated with ellagitannins in raspberry extracts Phytochemistry. ,vol. 68, pp. 218- 228 ,(2007) , 10.1016/J.PHYTOCHEM.2006.10.014