Environmental Triggers of Type 1 Diabetes

摘要: Type 1 diabetes (T1D) is perceived as a progressive immune-mediated disease, the clinical diagnosis of which preceded by an asymptomatic preclinical period highly variable duration. It has long been postulated that disease process leading to overt T1D triggered infectious agent, strongest candidate being diabetogenic enterovirus. The initiation and progression disorder likely requires, in addition genetic susceptibility, trigger, exogenous antigen capable driving development this disease. This may be dietary similar gluten celiac Recent data further suggests autoimmunity inflammation reflected proinflammatory metabolic serum profile. cause remains open, but given intestinal microbiome appears differ between individuals who progress nonprogressors, one speculate changes gut microflora might contribute inflammatory process.