Compliance and persistence with concomitant statin and oral antihyperglycemic therapy.

摘要: OBJECTIVES To compare compliance and persistence with statin oral antihyperglycemic therapies in patients type 2 diabetes who received concomitant therapy. STUDY DESIGN Retrospective cohort study using a large US commercial claims database. METHODS Patients dispensed prescriptions for both on the same date 2006 (index = first of such dispensing) were included analysis (N 52,414). required to have continuous enrollment database 1 year prior (baseline) years after (follow-up) index date. The 2-year medication possession ratio (MPR) was compared between For analysis, treatment discontinuation defined by gap >30 days last supply from previous dispensing subsequent refill. likelihood versus therapy estimated fitting robust Cox proportional hazards regression model, adjusted baseline variables. RESULTS MPR 70% 78% (P 80% 52% 63% <.0001). median time significantly shorter (284 vs 495 days, P <.001). There greater risk discontinue than (adjusted hazard ratio: 1.47 [95% confidence interval 1.45-1.48]). CONCLUSIONS Compliance lagged behind treated concomitantly therapies.