HLA-DR and ICAM-1 Expression on Bronchial Epithelial Cells in Asthma and Chronic Bronchitis
作者： Antonio M Vignola , Alison M Campbell , Pascal Chanez , Jean Bousquet , Pascale Paul-Lacoste
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摘要: HLA-DR and ICAM-I molecules play an important role in cellular interactions, their expression can be induced by inflammatory stimuli. We evaluated the spontaneous of ICAM-1 on epithelial cells obtained bronchial brushing from 27 asthmatic patients, 10 chronic bronchitis (CB) 19 normal subjects. In all cases > 90% pure were obtained. characterized using monoclonal antibodies revealed immunocytochemistry (APAAP technique). asthma, percentage expressing was significantly increased comparison with values (p < 0.001) CB 0.001; HLA-DR; p 0.003; ICAM-1) correlated clinical score Aas 0.001, FEV1 0.002; ICAM-1). CB, both markers slightly but subjects 0.02, 0.03, ...
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