Modifying effects of sulfotransferase 1A1 gene polymorphism on the association of breast cancer risk with body mass index or endogenous steroid hormones.

摘要: Sulfotransferase (SULT) 1A1 is involved in the inactivation and elimination of estrogens catechol estrogens. A common functional polymorphism (Arg213His) has been linked our previous study postmenopausal Caucasian women to an elevated risk breast cancer association appeared be modified by factors related high endogenous estrogen exposures. We further evaluated this levels BMI steroid hormones with a population-based case–control Chinese women, involving 1102 incident cases aged 25–64 years 1147 age-matched population controls. The SULT1A1 genotype was not associated overall population. possible suggested for (adjusted odds ratio [OR] = 1.4, 95% CI  = 0.9–2.1 subject carrying variant His allele). found significantly modify (≥25 kg/m2) (p interaction = 0.02), adjusted OR 3.6 (95%  = 1.5–8.7) Arg/His compared 1.1 (0.8–1.5) Arg/Arg (no His/His identified population). Similarly, long duration (≥30 years) menstruation also substantially differed interaction = 0.05), 4.0  = 1.3–12.8) 1.4 (0.8–2.5) genotype. Positive associations blood were generally more pronounced among allele. No similar effect modification premenopausal cancer, however. These data suggest that SULT1A1 Arg213His may sex hormone exposures on risk.