Expression of Cytokeratin 14 and 19 in Process of Oral Carcinogenesis.
作者： Kyoko Yoshida , Kazumichi Sato , Morio Tonogi , Yoichi Tanaka , Gen-yuki Yamane
DOI: 10.2209/TDCPUBLICATION.56.105
关键词:
摘要: Cytokeratins (CK) are abundant in keratinized cells, particularly CK14 and CK19, which expressed stratified squamous epithelial cells. In this study, expression of 19 was examined human dysplastic tissues. Surgical specimens from patients with clinically diagnosed oral leukoplakia or early cancer were stained hematoxylin eosin classified into normal, low grade dysplasia (LGD), high (HGD), cell carcinoma (SCC). The sections by immunostaining reverse transcription-polymerase chain reaction (RT-PCR) for CK19. Expression the results RT-PCR showed a decrease order LGD, HGD, SCC, whereas those CK19 an increase that order. These suggest decreased increased serve as indicators potential malignant transformation.
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