N,O-Diacylated-N-hydroxyarylsulfonamides: Nitroxyl precursors with potent smooth muscle relaxant properties
作者： Jon M. Fukuto , Raina Hszieh , Priya Gulati , Kenneth T. Chiang , Herbert T. Nagasawa
DOI: 10.1016/0006-291X(92)90453-R
关键词:
摘要: N,O-Diacylated-N-hydroxyarylsulfonamides are capable of slowly releasing nitroxyl (HNO) by simple, non-enzymatic hydrolysis in Krebs solution at 37 degrees C. Release nitric oxide (NO) was not seen. These compounds were also found to elicit vasorelaxation rabbit thoracic aorta vitro, presumably as a result their ability release HNO. This effect enhanced the addition superoxide dismutase (SOD). Thus, these results consistent with previous work indicating that HNO is potent vasorelaxant.
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