Eastern Equine Encephalitis in a Captive Harbor Seal (Phoca vitulina)
作者： Michael P. McBride , Michele A. Sims , Robert W. Cooper , Akinyi C. Nyaoke , Cheryl Cullion
DOI: 10.1638/2008-0021.1
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摘要: Abstract A 31-yr-old male, captive harbor seal (Phoca vitulina) was evaluated for a 48-hr period of anorexia followed by the onset seizures. prolonged seizure failed to respond anticonvulsant therapy and animal euthanized. At necropsy, no significant gross lesions were identified. Reverse transcriptase–polymerase chain reaction testing brain samples positive eastern equine encephalitis virus (EEEV) RNA, serum anti-EEEV antibodies plaque reduction neutralization. Histopathologic evaluation revealed severe multifocal with leptomeningitis, characterized neutrophilic infiltrates in neuropil, neuronal necrosis, satellitosis, neuronophagia, perivascular cuffs lymphocytes, macrophages, neutrophils. Additionally there moderate, multifocal, adrenal cortical necrosis. Immunohistochemical staining EEEV demonstrated viral antigen within necrotic neurons glial cells. Virus isolated from frozen tissue, sequenced ...
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sci-hub.se 参考文章(34)
Michael T. Taussig, The Nervous System ,(1991)
Crabbs Cl, Montali Rj, Docherty De, Tsai Tf, Dein Fj, Clark Gg, Carpenter Jw, Mortality of captive whooping cranes caused by eastern equine encephalitis virus. Javma-journal of The American Veterinary Medical Association. ,vol. 189, pp. 1006- 1010 ,(1986)
V S Hinshaw, W J Bean, R G Webster, J E Rehg, P Fiorelli, G Early, J R Geraci, D J St Aubin, Are seals frequently infected with avian influenza viruses Journal of Virology. ,vol. 51, pp. 863- 865 ,(1984) , 10.1128/JVI.51.3.863-865.1984
C H Calisher, Medically important arboviruses of the United States and Canada. Clinical Microbiology Reviews. ,vol. 7, pp. 89- 116 ,(1994) , 10.1128/CMR.7.1.89
Geraci, D. St Aubin, I. Barker, R. Webster, V. Hinshaw, W. Bean, H. Ruhnke, J. Prescott, G Early, A. Baker, S Madoff, R. Schooley, Mass mortality of harbor seals: pneumonia associated with influenza A virus Science. ,vol. 215, pp. 1129- 1131 ,(1982) , 10.1126/SCIENCE.7063847
Padraig J. Duignan, Samuel Sadove, Jeremiah T. Saliki, Joseph R. Geraci, Phocine Distemper in Harbor Seals (Phoca vitulina) from Long Island, New York Journal of Wildlife Diseases. ,vol. 29, pp. 465- 469 ,(1993) , 10.7589/0090-3558-29.3.465
A. D. M. E. OSTERHAUS, J. GROEN, F. G. C. M. UYTDEHAAG, I. K. G. VISSER, M. W. G. V. D. BILDT, A. BERGMAN, B. KLINGEBORN, Distemper virus in Baikal seals Nature. ,vol. 338, pp. 209- 210 ,(1989) , 10.1038/338209B0
Cynthia M. Tate, Elizabeth W. Howerth, David E. Stallknecht, Andrew B. Allison, John R. Fischer, Daniel G. Mead, Eastern Equine Encephalitis in a Free-ranging White-tailed Deer (Odocoileus virginianus) Journal of Wildlife Diseases. ,vol. 41, pp. 241- 245 ,(2005) , 10.7589/0090-3558-41.1.241
P. M. Thompson, H. J. C. Cornwell, H. M. Ross, D. Miller, SEROLOGIC STUDY OF PHOCINE DISTEMPER IN A POPULATION OF HARBOR SEALS IN SCOTLAND Journal of Wildlife Diseases. ,vol. 28, pp. 21- 27 ,(1992) , 10.7589/0090-3558-28.1.21
E. D. McGee, C. H. Littleton, J. B. Mapp, R. J. Brown, Eastern equine encephalomyelitis in an adult cow. Veterinary Pathology. ,vol. 29, pp. 361- 363 ,(1992) , 10.1177/030098589202900414