Distinct Trends of DNA Methylation Patterning in the Innate and Adaptive Immune Systems.

摘要: DNA methylation and the localization post-translational modification of nucleosomes are interdependent factors that contribute to generation distinct phenotypes from genetically identical cells. With 112 whole-genome bisulfite sequencing datasets BLUEPRINT Epigenome Project, we analyzed global development patterns during lineage commitment maturation a range immune system effector cells cancers arise them. We show clear trends in the innate adaptive arms human system, both globally relation consistently positioned nucleosomes. Most notable progressive loss developing lymphocytes consistent occurrence non-CG specific cell types. Cancer samples two lineages further polarized, suggesting involvement lineage-specific epigenetic mechanisms. anticipate broad utility for this resource as basis comparative analyses.