Effect of exercising at minimum recommendations of the multiple sclerosis exercise guideline combined with structured education or attention control education - secondary results of the step it up randomised controlled trial.

摘要: Recent exercise guidelines for people with multiple sclerosis (MS) recommend a minimum of 30 min moderate intensity aerobic and resistance twice per week. This trial compared the secondary outcomes combined 10-week guideline based intervention Social Cognitive Theory (SCT) education programme same involving an attention control education. Physically inactive MS, scoring 0–3 on Patient Determined Disease Steps Scale, no MS relapse or change in medication, were randomised to plus SCT conditions. Outcomes included fatigue, depression, anxiety, strength, physical activity, constructs impact measured by blinded assessor pre post-intervention 3 6 month follow up. One hundred seventy-four expressed interest, 92 eligible 65 enrolled. Using linear mixed effects models, differences between groups all measures at follow-up not significant. Post-hoc, exploratory, within group analysis identified improvements both post fatigue (mean ∆(95% CI) -4.99(−9.87, −0.21), p = 0.04, Control −7.68(−12.13, −3.23), p = 0.00), strength (SCT -1.51(−2.41, −0.60), p < 0.01, −1.55(−2.30, −0.79), p < 0.01), activity 9.85(5.45, 14.23), 12.92(4.69, 20.89), goal setting 7.30(4.19, 10.4), 5.96(2.92, 9.01), p < 0.01) planning 5.88(3.37, 8.39), 3.76(1.27, 6.25), that maintained above baseline up (all p < 0.05). Only improved MS(−4.45(−8.68, −0.22), −4.12(−8.25, 0.01), anxiety(−1.76(−3.20, −0.31), −1.99(−3.28, −0.71), depression(−1.51(−2.89, −0.13), −1.02(−2.05, 0.01)) cognition(5.04(2.51, 7.57), 3.05(0.81, 5.28), medium effect cognition fitness (Hedges’ g 0.75(0.24, 1.25), 0.51(0.01, 1.00) 3 month There statistically significant once age, gender, time since diagnosis type accounted for. However, only there MS. Exercising amount has positive PA is sustained 6 months following cessation program. ClinicalTrials.gov, NCT02301442 , retrospectively registered November 13th 2014.