Cytokines and Cardiac Contractile Function

摘要: A working understanding of the molecular and cell biology inflammatory cytokines is growing importance to both cardiovascular scientists practicing clinicians. Accumulating evidence indicates that these locally acting polypeptide mediators, or “autacoids,” play a role not only in pathogenesis atherosclerosis cardiac dysfunction accompanies systemic sepsis, viral myocarditis, allograft rejection but also advanced heart failure syndromes resulting from diverse pathogenic insults. (“Autacoid” derived Greek words autos [“self”] akos [“remedy”]; autacoids are acting, biologically active agents [both peptides nonpeptides] distinct neurotransmitters hormones circulation.1 ) More than 25 years ago, Lefer Rovetto2 reported sera septic patients experimental animals contained “myocardial depressant factor,” nature which has eluded definitive identification intervening years. During past decade, Parrillo colleagues3 4 used intact vitro isolated preparations systematically investigate factors contribute myocardial depression sepsis (ie, response syndrome) concluded TNF-α IL-1β were shown be present responsible for most, if all, reversible often seen with this syndrome. These data consistent earlier reports (reviewed Levine et al5 soluble mediators medium conditioned by activated immunocytes altered contractile responsiveness beating muscle cells β-adrenergic agonists, an effect could mimicked preparation recombinant IL-1β. Interest findings been amplified elevated circulating as well intracardiac levels failure.6 7 8 9 10 Systemic infusions one …