Increased Urinary Neutrophil Gelatinase Associated Lipocalin Levels in a Rat Model of Upper Urinary Tract Infection
作者： Manabu Ichino , Yoko Kuroyanagi , Mamoru Kusaka , Terumi Mori , Kiyohito Ishikawa
DOI: 10.1016/J.JURO.2009.01.010
关键词:
摘要: Purpose: Recurrent upper urinary tract infection is a common complication of vesicoureteral reflux that often leads to irreversible renal scarring. In our previous study rat model bacterial we performed global gene expression profiling the kidney during onset We have further investigated product an up-regulated product, NGAL, in this animal evaluate its potential usefulness as biomarker scarring.Materials and Methods: Renal NGAL mRNA protein levels were examined by real-time polymerase chain reaction, Western blot immunohistochemistry. Urinary monitored direct enzyme-linked immunosorbent assay.Results: Rat found be increased soon after injection. They then decreased rapidly but subsequently persisted at high until 6-week time point On histological analysis was overproduced macrophages and...
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