Potential prognostic value of mitogen-activated protein kinase activity for disease-free survival of primary breast cancer patients.
作者： Heinz Mueller , Nathalie Flury , Serenella Eppenberger-Castori , Willy Kueng , Fran�oise David
DOI: 10.1002/1097-0215(20000720)89:4<384::AID-IJC11>3.0.CO;2-R
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摘要: Signaling through pathways involving mitogen-activated protein kinases (MAP kinases) has been implicated in the pathogenesis of cancer. Thus, activity MAP kinase is essential malignant potential human breast tumors. p42/44(MAPK) was significantly higher expressed tumor samples than matching normal tissues adjacent to tumor. expression correlated with enhanced only a subset tumors, indicating that over-expression does not reflect activation status these enzymes. elevated 131 tissue from primary tumors when compared 18 A trend for node-positive patients observed node-negative patients. Similarly, activities were specimens who had relapse within follow-up time 40 months no relapse. survival analysis demonstrated potentially prognostic relapse-free
sci-hub.se 参考文章(24)
Judith S. Sebolt-Leopold, David T. Dudley, Roman Herrera, Keri Van Becelaere, Amy Wiland, Richard C. Gowan, Haile Tecle, Stephen D. Barrett, Alexander Bridges, Sally Przybranowski, W.R. Leopold, Alan R. Saltiel, Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo. Nature Medicine. ,vol. 5, pp. 810- 816 ,(1999) , 10.1038/10533
RJ Coffey, D Yee, KB Reddy, CK Osborne, SG Hilsenbeck, Inhibition of estrogen-induced breast cancer cell proliferation by reduction in autocrine transforming growth factor alpha expression. Cell Growth & Differentiation. ,vol. 5, pp. 1275- 1282 ,(1994)
I. Clark-Lewis, J.S. Sanghera, S.L. Pelech, Definition of a consensus sequence for peptide substrate recognition by p44mpk, the meiosis-activated myelin basic protein kinase. Journal of Biological Chemistry. ,vol. 266, pp. 15180- 15184 ,(1991) , 10.1016/S0021-9258(18)98601-1
S.K. Gupta, C Gallego, G.L. Johnson, L.E. Heasley, MAP kinase is constitutively activated in gip2 and src transformed rat 1a fibroblasts. Journal of Biological Chemistry. ,vol. 267, pp. 7987- 7990 ,(1992) , 10.1016/S0021-9258(18)42397-6
J M Schlaeppi, U Eppenberger, G Martiny-Baron, W Küng, Chemiluminescence immunoassay for vascular endothelial growth factor (vascular permeability factor) in tumor-tissue homogenates. Clinical Chemistry. ,vol. 42, pp. 1777- 1784 ,(1996) , 10.1093/CLINCHEM/42.11.1777
Marcel Verheij, Ron Bose, Xin Hua Lin, Bei Yao, W. David Jarvis, Steven Grant, Michael J. Birrer, Eva Szabo, Leonard I. Zon, John M. Kyriakis, Adriana Haimovitz-Friedman, Zvi Fuks, Richard N. Kolesnick, Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature. ,vol. 380, pp. 75- 79 ,(1996) , 10.1038/380075A0
M H Cobb, T G Boulton, D J Robbins, Extracellular signal-regulated kinases: ERKs in progress Molecular Biology of the Cell. ,vol. 2, pp. 965- 978 ,(1991) , 10.1091/MBC.2.12.965
Seunghee Kim-Schulze, William L. Lowe, H. William Schnaper, Estrogen Stimulates Delayed Mitogen-Activated Protein Kinase Activity in Human Endothelial Cells via an Autocrine Loop That Involves Basic Fibroblast Growth Factor Circulation. ,vol. 98, pp. 413- 421 ,(1998) , 10.1161/01.CIR.98.5.413
N. J. Kenney, T. Saeki, M. Gottardis, N. Kim, P. Garcia-Morales, M. B. Martin, N. Normanno, F. Ciardiello, A. Day, M. L. Cutler, D. S. Salomon, Expression of transforming growth factor α antisense mRNA inhibits the estrogen-induced production of TGFα and estrogen-induced proliferation of estrogen-responsive human breast cancer cells Journal of Cellular Physiology. ,vol. 156, pp. 497- 514 ,(1993) , 10.1002/JCP.1041560309
Sally Cowley, Hugh Paterson, Pauline Kemp, Christopher J Marshall, Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells Cell. ,vol. 77, pp. 841- 852 ,(1994) , 10.1016/0092-8674(94)90133-3