Immunohistochemical studies on the distribution of neuropeptides and serotonin in the suprachiasmatic nucleus of the Brattleboro rat.

摘要: The distribution of vasoactive intestinal polypeptide (VIP), gastrin-releasing peptide (GRP)/bombesin, somatostatin, vasopressin, neuropeptide Y (NPY) and serotonin was examined immunohistochemically in the suprachiasmatic nucleus (SCN) male rats genetically deficient for vasopressin (Brattleboro strain). VIP-containing neurons their varicose fibers were preferentially distributed large numbers ventromedial part SCN. GRP/bombesin-containing also gathered ventral SCN, particularly ventromedical region nucleus. Somatostatin-containing prominent rostral middle portions where highest concentration immunoreactivity restricted part. No vasopressin-immunoreactivity found at all throughout Profuse NPY-containing observed ventrolateral but no immunoreactive this nuclear region. Serotonergic showed a topographic arrangement SCN: serotonin-immunoreactive nerve plexus predominantly These findings indicate that SCN Brattleboro is composed distinct subdivisions cell bodies fibers. five peptides indoleamine within strain compared with normal Long-Evans rats. Furthermore, both strains exogeneously administered arginine-vasopressin, conspicuous difference regional patterns detected. possible role discussed.