作者: Daniel R. Croft , Michael F. Olson
DOI: 10.1016/J.CCR.2008.10.009
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摘要: Switching between elongated and rounded modes of movement allows invasive tumor cells to adapt varying microenvironments. In a recent issue Cell , Sanz-Moreno et al. identify DOCK3, NEDD9, WAVE2, ARHGAP22 as key molecules regulating Rac Rho signaling that determine the mode driving melanoma cell metastasis.