CD133(+)/CD44(+)/Oct4(+)/Nestin(+) stem-like cells isolated from Panc-1 cell line may contribute to multi-resistance and metastasis of pancreatic cancer.
作者： Dongqing Wang , Haitao Zhu , Ying Zhu , Yanfang Liu , Huiling Shen
DOI: 10.1016/J.ACTHIS.2012.09.007
关键词:
摘要: Pancreatic cancer is an aggressive malignant disease. Owing to the lack of early symptoms, accompanied by extensive metastasis and high resistance chemotherapy, pancreatic adenocarcinoma becomes fourth leading cause cancer-related deaths. In this study, we identified a subpopulation cells isolated from Panc-1 cell line named stem-like cells. These expressed levels CD133/CD44/Oct4/Nestin. Compared cells, were resistant gemcitabine MDR1; furthermore, have anti-apoptotic, but weak proliferative potential. results indicated that as novel group, may be potential major multidrug metastasis.
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