Role of MAPK ERK1/2 and p38 in the Realization of Growth Potential of Various Types of Regeneration-Competent Cells in Mouse Neural Tissue during Ethanol-Induced Neurodegeneration In Vitro.
作者： G. N. Zyuz’kov , L. A. Miroshnichenko , T. Yu. Polyakova , L. A. Stavrova , E. V. Simanina
DOI: 10.1007/S10517-019-04497-X
关键词:
摘要: Ethanol-induced neurodegeneration was modeled in vitro to study the roles of ERK1/2 and p38 realization growth potential neural progenitor cells secretion neurotrophic factors by glial elements. Addition neurotoxic dose C2H5OH (65 mM) culture medium abolished effects specific inhibitors on formation colonies (neurospheres) proliferative activity CFU cultured derived from paraventricular region mouse brain. The established that these protein kinases are not implicated ethanol-induced stimulation CFU, differentiation progenitors, synthesis humoral functional regulators cells.
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