Epigenetic and pharmacoepigenomic studies of major psychoses and potentials for therapeutics

摘要: Individuals with neuropsychiatric diseases have epigenetic programming disturbances, both in the brain, which is primary affected organ, and secondary tissues. Epigenetic modulations are molecular modifications made to DNA, RNA proteins that fine-tune genotype into phenotype do not include DNA base changes. For instance, gene-expression modulation linked codes chromatin consist of post-replication methylation histone protein (e.g., methylation, acetylation so on), particularly gene-promoter regions. coding modulated globally, a gene-specific manner by environmental exposures nutrition, toxins, drugs on. Analysis aberrations helps identify dysfunctional genes pathways, establish more robust cause–effect relationships than genetic studies alone, new pharmaceutical targets drugs, including nucleic acid reagents such as inhibitory RNAs. The emerging sc...