IL-8 predicts early mortality in patients with acute hypercapnic respiratory failure treated with noninvasive positive pressure ventilation.

摘要: Patients with Acute Hypercapnic Respiratory Failure (AHRF) who are unresponsive to appropriate medical treatment, often treated Noninvasive Positive Pressure Ventilation (NPPV). Clinical predictors of the outcome this treatment scarce. Therefore, we evaluated role biomarkers IL-8 and GDF-15 in predicting 28-day mortality patients AHRF receive NPPV. The study population were 46 NPPV for AHRF. background data was registered blood samples taken analysis inflammatory biomarkers. selected analysis, related risk (primary endpoint) using Cox proportional hazard models adjusted gender, age various clinical parameters. Of patients, there 3 subgroup regards primary diagnosis: Exacerbation COPD (AECOPD, n = 34), Heart (AHF, n = 8) Obesity Hypoventilation Syndrome (AEOHS, n = 4). There significant difference basic characteristic subgroups, but not parameters that used decisions. 13 died within 28 days admission (28%). Hazard Ratio 28-days per 1-SD increment 3.88 (95% CI 1.86–8.06, p < 0.001). When values divided into tertiles, highest tertile had a association mortality, HR 10.02 1.24–80.77, p trend 0.03), compared lowest tertile. This correlation maintained when largest AECOPD analyzed. correlated same way, put model as IL-8, significance disappeared. is target explore further predictor