Point: myeloperoxidase -463G --> a polymorphism and lung cancer risk.

摘要: Myeloperoxidase (MPO) is released from neutrophils in lung tissue response to exposure various pulmonary insults, including tobacco smoking. This enzyme involved the activation of an intermediate metabolite benzo(a)pyrene highly reactive diol epoxide. A −463G → polymorphism promoter region MPO gene has been identified. The allele associated with a decreased transcriptional activity attributable disruption SP1-binding site. We therefore examined whether carriers may be at reduced risk cancer case-control study 150 cases and 172 control individuals, all Caucasian smokers. Relative subjects G/G genotype, significant was found for G/A genotype [odds ratio (OR) = 0.5, 95% confidence interval (CI): 0.29–0.88]. reduction risk, although not statistically significant, also observed A/A (OR 0.84, CI: 0.31–2.32). one or two copies 0.55 (95% 0.33–0.93). Because low prevalence we performed meta-analysis 2686 3325 controls. summary OR suggested slight protective effect 0.86, 0.67–1.1), but this finding strongly influenced by results single large study. restricted studies comprising homogeneous set yielded 0.68 0.5–0.93). However, because heterogeneity individual results, additional are warranted provide more definitive conclusion.