Regulation of ferritin and transferrin receptor mRNAs.

作者: E C Theil

DOI: 10.1016/S0021-9258(19)34036-0

关键词:

摘要: Iron regulates the synthesis of two proteins critical for iron metabolism, ferritin and transferrin receptor, through novel mRNA/protein interactions. The mRNA regulatory sequence (iron-responsive element (IRE)) occurs in 5'-untranslated region all mRNAs is repeated as five variations 3'-untranslated receptor mRNA. When excess, storage increase. At same time, uptake decrease. Location common IRE different noncoding regions may explain how can have opposite metabolic effects; when mRNA, translation enhanced by excess whereas presence IREs leads to iron-dependent degradation. How where actually acts not yet known. A soluble 90-kDa protein which has been recently purified homogeneity from liver red cells specifically blocks binds sequences but does appear be an iron-binding protein. first specific eukaryotic regulator identified confirms predictions 20 years old. Concerted regulation also define a more general strategy using coordinate metabolically related proteins.

参考文章(57)
F.V. Schaefer, E.C. Theil, The effect of iron on the synthesis and amount of ferritin in red blood cells during ontogeny. Journal of Biological Chemistry. ,vol. 256, pp. 1711- 1715 ,(1981) , 10.1016/S0021-9258(19)69865-0
G E Shull, E C Theil, Translational control of ferritin synthesis by iron in embryonic reticulocytes of the bullfrog. Journal of Biological Chemistry. ,vol. 257, pp. 14187- 14191 ,(1982) , 10.1016/S0021-9258(19)45363-5
Elizabeth C. Theil, The Ferritin Family of Iron Storage Proteins Advances in Enzymology - and Related Areas of Molecular Biology. ,vol. 63, pp. 421- 449 ,(1990) , 10.1002/9780470123096.CH7
L F Dickey, Y H Wang, G E Shull, I A Wortman, E C Theil, The importance of the 3'-untranslated region in the translational control of ferritin mRNA. Journal of Biological Chemistry. ,vol. 263, pp. 3071- 3074 ,(1988) , 10.1016/S0021-9258(18)69035-0