作者: E C Theil
DOI: 10.1016/S0021-9258(19)34036-0
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摘要: Iron regulates the synthesis of two proteins critical for iron metabolism, ferritin and transferrin receptor, through novel mRNA/protein interactions. The mRNA regulatory sequence (iron-responsive element (IRE)) occurs in 5'-untranslated region all mRNAs is repeated as five variations 3'-untranslated receptor mRNA. When excess, storage increase. At same time, uptake decrease. Location common IRE different noncoding regions may explain how can have opposite metabolic effects; when mRNA, translation enhanced by excess whereas presence IREs leads to iron-dependent degradation. How where actually acts not yet known. A soluble 90-kDa protein which has been recently purified homogeneity from liver red cells specifically blocks binds sequences but does appear be an iron-binding protein. first specific eukaryotic regulator identified confirms predictions 20 years old. Concerted regulation also define a more general strategy using coordinate metabolically related proteins.