Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders.
作者： N.J Brandon , E.J Handford , I Schurov , J.-C Rain , M Pelling
DOI: 10.1016/J.MCN.2003.09.009
关键词:
摘要: Disrupted In Schizophrenia 1 (DISC1) was identified as a potential susceptibility gene for schizophrenia due to its disruption by balanced t(1;11) (q42;q14) translocation, which has been shown cosegregate with major psychiatric disease in large Scottish family. We have demonstrated that DISC1 exists neurodevelopmentally regulated protein complex Nudel. The is abundant at E17 and early postnatal life but greatly reduced the adult. Nudel previously bind Lis1, underlying lissencephaly humans. Critically, we show predicted peptide product resulting from translocation removes interaction domain interacts through leucine zipper binds novel DISC1-interaction on Nudel, independent Lis1 binding site. able act bridge between allow formation of trimolecular complex. implicated play role neuronal migration, together developmental variation abundance DISC1–Nudel complex, may implicate defective neurodevelopmental cause schizophrenia.
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