The white blood cell count: its relationship to plasma insulin and other cardiovascular risk factors in healthy male individuals

摘要: Targher G, Seidell JC, Tonoli M, Muggeo De Sandre Cigolini M (Division of Endocrinology and Metabolic Diseases, Institute Clinical Medicine, University Verona, Italy; Department Chronic Diseases Environmental Epidemiology-RIVM, Bilthoven, The Netherlands). white blood cell count: relationship to plasma insulin other cardiovascular risk factors in healthy males. J Intern Med 1996; 239: 435–41. Objectives. To evaluate the relationships total differential (WBC) count components so-called resistance syndrome. Subjects design. study population consisted a random sample 90 38-year-old men with normal glucose tolerance. Interventions. A 75 g oral tolerance test was performed all participants. Main outcome measures. Total WBC count, lipids, pressure, glucose, C-peptide (at fasting 2 h after load). Results. correlated consistently 2-h (r=0.38; P<0.001), postload (r=0.26 r=0.33; P<0.01–0.001, respectively) (r=0.28 r=0.32; P<0.01–0.001) concentrations. Smokers had significantly higher leukocytes (P<0.01), neutrophils lymphocytes than nonsmokers. Furthermore, positively body mass index, triglycerides, fibrinogen, negatively HDL cholesterol concentration. As most variables essentially and/or lymphocytes, whereas concentrations monocytes, but not neutrophils. In multiple linear regression analysis, only (P<0.01) fibrinogen (P<0.05) were positive predictors adjusting for potentially confounding variables. Conclusions. results indicate that increased, albeit normal, associates cluster metabolic haemodynamic disorders typical syndrome, suggest increased may be yet another component this syndrome.