Genome-wide microRNA expression profiling in placentas of fetuses with Down syndrome

摘要: Abstract Introduction Down syndrome (DS) is the most common aneuploidy, caused by an extra copy of all or part chromosome 21 (chr21). Differential microRNA (miRNA) expression involved in many human diseases including DS. However, genome-wide changes miRNA DS fetal placentas have yet to be determined, and function these also unclear. Methods We profiled placenta samples from euploid fetuses using microarray technology predicted functions differentially expressed miRNAs bioinformatics tools. Results Thirty-four were significantly compared with normal (16 up-regulated 18 down-regulated). chr21-derived did not change. Predicted target genes included 7434 targeted 6071 down-regulated miRNAs. Seventy-six located on chr21 (10 controlled 34 miRNAs, 32 both). Target associated DS-related disorders, such as mental retardation, neurobehavioral manifestations, congenital abnormalities. Discussion To our knowledge, this first study comprehensively survey placental fetuses. Our results provide new insight into Additionally, findings indicate that may potentially affect various pathways related pathogenesis.