Increased levels of microRNA-424 are associated with the pathogenesis of fetal growth restriction.
作者： L. Huang , Z. Shen , Q. Xu , X. Huang , Q. Chen
DOI: 10.1016/J.PLACENTA.2013.04.009
关键词: Andrology 、 Cancer research 、 Pathogenesis 、 Fetal growth 、 Mrna level 、 Placenta 、 Downregulation and upregulation 、 Fibroblast growth factor receptor 1 、 Protein kinase A 、 Biology 、 microRNA
摘要: Abstract Studies show a number of miRNAs are expressed in the placenta including miRNA-424, hypoxia–regulated miRNA, suggesting miRNA-424 may have potential regulatory role fetal growth restriction (FGR). The levels and its target gene, mitogen-activated protein kinase 1 (MEK1), fibroblast factor receptor (FGFR1) were examined. significantly increased placentae from women with FGR. Both mRNA MEK1 FGFR1 reduced complicated Furthermore, negatively correlated Our study suggests upregulated be associated pathogenesis
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