Mutations in APC , CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study
作者： Margreet Lüchtenborg , Matty P Weijenberg , Petra A Wark , A Merdan Saritas , Guido MJM Roemen
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摘要: Background The early to intermediate stages of the majority colorectal tumours are thought be driven by aberrations in Wnt (APC, CTNNB1) and Ras (K-ras) pathways. A smaller proportion cancers shows mismatch repair deficiency. The aim this study was analyse co-occurrence these genetic alterations relation tumour patient characteristics.
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