Prevalence of G-to-T transversions among K-ras oncogene mutations in human colorectal tumors in Yugoslavia.
作者： Nadežda Urošević , Aleksandar Dujić , Koviljka Krtolica , Andjelija Škaro-Milić , Slavica Knežević-Ušaj
关键词: Epithelioma 、 Oncogene 、 Mutation 、 Colorectal cancer 、 Point mutation 、 Population 、 Genetics 、 Gene 、 Medicine 、 Carcinoma
摘要: Human colorectal carcinoma tissue sampled from 37 patients, routinely graded into Dukes' stages A, B and C histologically examined for the level of differentiation, were analyzed presence point mutations in K-ras oncogene. Seventeen cases out found to have a mutation either 12th or 13th codon gene, giving an overall frequency 46%. The incidence was 33, 46 58% respectively. Although appears be similar that reported USA population, spectrum codons 12 13 gene Yugoslav population differ significantly. G-to-T trans-versions make up 77% all present, with distribution as follows: 18% at first base 59% second 13. G-to-A transitions is only other identified, occurring mainly tumors 3 stages.
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