Desferrioxamine Treatment Reduces Histological Evidence of Lung Damage in Rats after Acute Nitrogen Dioxide (NO2) intoxication
作者： J. Meulenbelt , J.A.M.A. Dormans , L. van Bree , P.J.A. Rombout , B. Sangster
DOI: 10.1177/096032719301200508
关键词:
摘要: 1 In previous studies a rat inhalation model was developed to investigate the efficacy of treatment in acute NO2 intoxication.2 Desferrioxamine administered intravenously study its effect on histological alterations lung tissue rats after exposure.3 Twenty four hours exposure 175 ppm for 10 minutes injury observed by light microscopy desferrioxamine treated less pronounced than saline rats.4 appeared provide more protection with dose 100 mg kg-1 24 h-1 200 h-1.
sagepub.com
sci-hub.se 参考文章(16)
W. A. PRYOR, J. W. LIGHTSEY, Mechanisms of nitrogen dioxide reactions: initiation of lipid peroxidation and the production of nitrous Acid. Science. ,vol. 214, pp. 435- 437 ,(1981) , 10.1126/SCIENCE.214.4519.435
J. Meulenbelt, L. van Bree, J.A.M.A. Dormans, A.B.T.J. Boink, B. Sangster, Biochemical and histological alterations in rats after acute nitrogen dioxide intoxication. Human & Experimental Toxicology. ,vol. 11, pp. 189- 200 ,(1992) , 10.1177/096032719201100307
H.G. Meyer-Brunot, H. Keberle, The metabolism of desferrioxamine B and ferrioxamine B Biochemical Pharmacology. ,vol. 16, pp. 527- 535 ,(1967) , 10.1016/0006-2952(67)90100-1
B. Bradley, S. J. Prowse, P. Bauling, K. J. Lafferty, Desferrioxamine Treatment Prevents Chronic Islet Allograft Damage Diabetes. ,vol. 35, pp. 550- 555 ,(1986) , 10.2337/DIAB.35.5.550
Barry Halliwell, John M. C. Gutteridge, Free radicals in biology and medicine ,(1985)
M. Tenenbein, S. Kowalski, A. Sienko, D.H. Bowden, I.Y.R. Adamson, M. Tenenbein, Pulmonary toxic effects of continuous desferrioxamine administration in acute iron poisoning The Lancet. ,vol. 339, pp. 699- 701 ,(1992) , 10.1016/0140-6736(92)90598-W
Barry Halliwell, Protection against tissue damage in vivo by desferrioxamine: what is its mechanism of action? Free Radical Biology and Medicine. ,vol. 7, pp. 645- 651 ,(1989) , 10.1016/0891-5849(89)90145-7
P A Ward, G O Till, R Kunkel, C Beauchamp, Evidence for role of hydroxyl radical in complement and neutrophil-dependent tissue injury. Journal of Clinical Investigation. ,vol. 72, pp. 789- 801 ,(1983) , 10.1172/JCI111050
B. Sweder Van Asbeck, Feddo C. Hillen, Harry C. M. Boonen, Yep De Jong, Jan A. M. A. Dormans, Nanneke A. A. Van Der Wal, Jo J. M. Marx, Bart Sangster, Continuous intravenous infusion of deferoxamine reduces mortality by paraquat in vitamin E-deficient rats. The American review of respiratory disease. ,vol. 139, pp. 769- 773 ,(1989) , 10.1164/AJRCCM/139.3.769
M. R. Summers, A. Jacobs, D. Tudway, P. Perera, C. Ricketts, Studies in Desferrioxamine and Ferrioxamine Metabolism in Normal and Iron‐Loaded Subjects British Journal of Haematology. ,vol. 42, pp. 547- 555 ,(1979) , 10.1111/J.1365-2141.1979.TB01167.X