Apolipoprotein E4 allele influences the response of plasma triglyceride levels to tamoxifen in breast cancer patients

摘要: Abstract Background Apolipoprotein E4 (APOE4) allele is an important risk factor for breast cancer and affects clearance of chylomicron remnants. Tamoxifen therapy increases serum triglyceride levels sometimes inducing severe hypertriglyceridemia in patients. Methods Thirty-three women with were recruited to examine the APOE polymorphism fasting plasma lipid profiles before after tamoxifen treatment 6 months. Results We found that changed accordance APOE4 Especially significantly decreased APOE4-positive patients (p = 0.025), while there was no change APOE4-negative (p = 0.189). The total cholesterol reduced APOE-4 positive 6-month (p = 0.014). low density lipoprotein high both Conclusions These findings indicate effects on are modified by polymorphism. Breast have when receiving therapy. Therefore, we suggest gene a critical validation