Internet-Enabled High-Resolution Brain Mapping and Virtual Microscopy
作者： Shawn Mikula , Issac Trotts , James M. Stone , Edward G. Jones
DOI: 10.1016/J.NEUROIMAGE.2006.11.053
关键词:
摘要: Abstract Virtual microscopy involves the conversion of histological sections mounted on glass microscope slides to high-resolution digital images. offers several advantages over traditional microscopy, including remote viewing and data sharing, annotation, various forms mining. We describe a method utilizing virtual for generation internet-enabled, brain maps atlases. microscopy-based atlases have resolutions approaching 100,000 dpi, which exceeds by three or more orders magnitude obtainable in conventional print atlases, MRI, flat-bed scanning. are superior five respects: (1) resolution, (2) (3) interaction, (4) integration, (5) Implementation is located at BrainMaps.org, based than 10 million megapixels (35 terabytes) scanned images serial primate non-primate brains with resolution 0.46 μm/pixel (55,000 dpi). The can be replicated labs seeking increase accessibility sharing neuroanatomical data. Online tools offer possibility visualizing exploring completely digitized sub-neuronal level facilitate large-scale connectional tracing, histochemical, stereological analyses.
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