CD4 lymphocytes in the blood of HIV(+) individuals migrate rapidly to lymph nodes and bone marrow: support for homing theory of CD4 cell depletion.

摘要: The mechanism(s) by which human im- munodeficiency virus (HIV) causes depletion of CD4 lymphocytes remains unknown. Evidence has been reported for a mechanism involving HIV binding to (and signaling) resting in lymphoid tissues, resulting up-regulation lymph node homing receptors and enhanced hom- ing after these cells enter the blood, induction apoptosis many during process, caused secondary signaling through receptors. Supportive evidence this as major pathogenic requires demon- stration that individuals do migrate nodes at rates. Stud- ies herein show freshly isolated lympho- cytes labeled with 111 Indium intravenously re- infused back into donors home peripheral rates two times faster than normal. They also iliac vertebral bone marrow. In contrast, hepatitis B virus-infected subjects displayed less normal blood lymphocyte migra- tion Furthermore, increased returned lev- els effective, highly active antiretroviral ther- apy treatment, showing correlated replication. This is first direct demonstration where how fast traffic tissues HIV-infected humans. results sup- port theory disappearance from patients result their migration out (homing) dying extravascular tissues. J. Leu- koc. Biol. 72: 271-278; 2002.