DNA repair of oxidative DNA damage in human carcinogenesis: Potential application for cancer risk assessment and prevention

摘要: Efficient DNA repair mechanisms comprise a critical component in the protection against human cancer, as indicated by high predisposition to cancer of individuals with germ-line mutations genes. This includes biallelic MUTYH gene, encoding glycosylase that is involved oxidative damage, which strongly predispose humans rare hereditary form colorectal cancer. Extensive research efforts including biochemical, enzymological and genetic studies model organisms established lesion 8-oxoguanine mutagenic, several operate prevent its potentially mutagenic carcinogenic outcome. Epidemiological on association sporadic cancers single nucleotide polymorphisms genes such OGG1, yielded conflicting results, suggest minor effect at best. A new approach based functional analysis enzymatic activity showed reduced (OGG) risk factor lung head neck Moreover, combination smoking low OGG was associated higher risk, suggesting potential strategy for assessment prevention well other types