Whey acidic protein extrinsically expressed from the mouse mammary tumor virus long terminal repeat results in hyperplasia of the coagulation gland epithelium and impaired mammary development

摘要: The whey acidic protein (WAP) is a milk that contains cysteine-rich motif. This characteristic WAP signature has also been found in some protease inhibitors and certain proteins involved tissue modeling. specifically synthesized mammary from late pregnant lactating animals, precocious synthesis results impaired lobuloalveolar development of the gland transgenic lines. To determine whether growth modulatory effects are confined to tissue, we expressed gene under control mouse tumor virus long terminal repeat mice. transgene was at high levels organs with exocrine function, such as salivary glands, prostate, seminal vesicle, coagulation gland. In addition development, observed hyperplasia dysplasia epithelium. These findings suggest or member family can, contexts, function an epithelial regulator. It appears present study regulatory restricted