Association of Epidermal Growth Factor-related Peptides and Type I Receptor Tyrosine Kinase Receptors with Prognosis of Human Colorectal Carcinomas

摘要: The frequency of expression and localization cripto-1 (CR-1), amphiregulin (AR), transforming growth factor alpha (TGF alpha), epidermal receptor (EGFR) erbB-2 were examined by immunohistochemistry in 45 carcinomas adjacent non-involved normal colon mucosa. Thirty (66.7%), 24 (53.3%), 23 (51.1%), (51.1%) 13 (28.9%) the showed positive staining for CR-1, AR, TGF alpha, EGFR erbB-2, respectively, whereas 7 (15.5%), 17 (37.7%), 15 (33.3%), 20 (44.4%) 0 (0%) corresponding mucosa specimens reactive. Among with lymph node involvement, 10 (76.9%), 8 (61.5%), (61.5%) (53.8%) exhibited TGF-alpha, respectively. There was a statistically significant association between either (P < 0.05) or metastasis. In addition, significantly higher observed Dukes' grade C 0.05). Finally, trends coexpression 0.01) AR detected carcinomas. These data suggest that may play an important role development colorectal through autocrine mechanism involving EGFR, demonstrate be more reliable indicators metastasis prognosis than human cancers.