Taurine protects against ischemia-reperfusion injury in rabbit livers.
作者： L. Tong , J. Li , H. Qiao , H. Jiang , F. Meng
DOI: 10.1016/J.TRANSPROCEED.2006.02.057
关键词:
摘要: Ischemia-reperfusion injury is of major clinical relevance during liver transplantation. In the present study, therapeutic efficacy taurine to protect against ischemia-reperfusion was investigated in rabbit livers. We demonstrated that intravenous injection attenuated dysfunction as evidenced by reductions serum alanine aminotransferase, aspartate transaminase, and alkaline phosphatase. The recovery morphological ultrastructural changes also promoted taurine. mechanism protective effect seems at least rely on antioxidation, since lipoperoxides contents tissues were significantly reduced among taurine-treated rabbits. These results suggest a potent useful reagent from injury.
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sci-hub.se 参考文章(24)
Stephen Schaffer, Junichi Azuma, Kyoko Takahashi, Mahmood Mozaffari, Why Is Taurine Cytoprotective? Advances in Experimental Medicine and Biology. ,vol. 526, pp. 307- 321 ,(2003) , 10.1007/978-1-4615-0077-3_39
M. Barinaga, Forging a Path to Cell Death Science. ,vol. 273, pp. 735- 737 ,(1996) , 10.1126/SCIENCE.273.5276.735
Joseph Nanobashvili, Christoph Neumayer, Alexander Fügl, Andreas Punz, Roland Blumer, Manfred Prager, Martina Mittlböck, Helmut Gruber, Peter Polterauer, Erich Roth, Tadeusz Malinski, Ihor Huk, Ischemia/reperfusion injury of skeletal muscle: plasma taurine as a measure of tissue damage. Surgery. ,vol. 133, pp. 91- 100 ,(2003) , 10.1067/MSY.2003.65
Anna Kordelia Kurz, Freimut Schliess, Dieter Häussinger, Osmotic regulation of the heat shock response in primary rat hepatocytes Hepatology. ,vol. 28, pp. 774- 781 ,(1998) , 10.1002/HEP.510280326
Thorsten Peters-Regehr, Johannes G. Bode, Ralf Kubitz, Dieter Häussinger, Organic osmolyte transport in quiescent and activated rat hepatic stellate cells (ito cells) Hepatology. ,vol. 29, pp. 173- 180 ,(1999) , 10.1002/HEP.510290111
Weiguo Zhou, Mark O. McCollum, Barry A. Levine, Merle S. Olson, Inflammation and platelet-activating factor production during hepatic ischemia/reperfusion Hepatology. ,vol. 16, pp. 1236- 1240 ,(1992) , 10.1002/HEP.1840160521
Robert W. Hobson, Ischemia-Reperfusion Injury of Skeletal Muscle Annals of Vascular Surgery. ,vol. 10, pp. 96- ,(1996) , 10.1016/S0890-5096(06)60444-5
Catherine J. Waterfield, John A. Turton, M.David C. Scales, John A. Timbrell, Reduction of liver taurine in rats by beta-alanine treatment increases carbon tetrachloride toxicity. Toxicology. ,vol. 77, pp. 7- 20 ,(1993) , 10.1016/0300-483X(93)90133-D
Christian Weik, Ulrich Warskulat, Johannes Bode, Thorsten Peters-Regehr, Dieter Häussinger, Compatible organic osmolytes in rat liver sinusoidal endothelial cells Hepatology. ,vol. 27, pp. 569- 575 ,(1998) , 10.1002/HEP.510270235
H.Paul Redmond, P.P. Stapleton, Paul Neary, David Bouchier-Hayes, Immunonutrition: The role of taurine Nutrition. ,vol. 14, pp. 599- 604 ,(1998) , 10.1016/S0899-9007(98)00097-5