Integrins: molecular determinants of glioma invasion.
作者： Giovanna M. D’Abaco , Andrew H. Kaye
DOI: 10.1016/J.JOCN.2007.06.019
关键词:
摘要: Gliomas, the most common form of brain tumour are characterised by a capacity to invade throughout normal tissue. This infiltrative nature is hallmark poor prognosis. A greater understanding molecular determinants that drive invasion may lead improved therapy. Integrins large family cell surface receptors mediate interaction between and extracellular matrix. facilitate matrix dependent organization cytoskeleton activation intracellular signalling required for regulation adhesion migration. Since integrins key regulators these processes, role play in field intense research.
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