PileLineGUI: a desktop environment for handling genome position files in next-generation sequencing studies

摘要: Next-generation sequencing (NGS) technologies are making sequence data available on an unprecedented scale. In this context, new catalogs of Single Nucleotide Polymorphism and mutations generated by resequencing studies usually stored in genome position files (e.g. Variant Call Format, SAMTools pileup, BED, GFF) comprising large lists genomic positions, which difficult to handle researchers. Here, we present PileLineGUI, a novel desktop application primarily designed for manipulating, browsing analysing (GPF), with specific support somatic mutation finding studies. The developed tool also integrates browser module specially inspecting GPFs. PileLineGUI is free, multiplatform be intuitively used biomedical at: http://sing.ei.uvigo.es/pileline/pilelinegui.html.