Elevated levels of cyclin A1 and A (A2) mRNA in acute myeloid leukaemia are associated with increased survival.
作者： Tsuyoshi Nakamaki , Yasuharu Hamano , Jun-ichi Hisatake , Akihiro Yokoyama , Kei-ichiro Kawakami
DOI: 10.1046/J.1365-2141.2003.04569.X
关键词:
摘要: Summary. Cyclin A (A2) and cyclin A1 are members of the G2 cyclins, which involved in control G2/M G1/S transitions as well mitosis. Human was cloned an A-type that is highly expressed acute myeloid leukaemia (AML). The clinical significance these cyclins remains to be clarified. We investigated relative levels transcripts 80 patients with de novo AML. Correlations parameters showed initial white blood cell count serum lactate dehydrogenase were inversely associated mRNA (r = −0·276, P = 0·019) (r = −0·241, P = 0·042) respectively. They independently increased overall survival [P = 0·035 for P = 0·016 A1]. Multivariate analysis using Cox's proportional hazard model elevated contributed significantly better prognosis Furthermore, probability group high both survived longer than low expression (P = 0·002). These data indicate good AML patients.
sci-hub.se 参考文章(47)
F Lacombe, F Belloc, P Dumain, M Puntous, PC Makhoul, MC Saux, P Bernard, MR Boisseau, J Reiffers, Detection of cytarabine resistance in patients with acute myelogenous leukemia using flow cytometry. Blood. ,vol. 84, pp. 716- 723 ,(1994) , 10.1182/BLOOD.V84.3.716.BLOODJOURNAL843716
Carsten Müller, Rong Yang, Gregory Idos, Nicola Tidow, Sven Diederichs, Olaf M. Koch, Walter Verbeek, Timothy P. Bender, H. Phillip Koeffler, c-myb transactivates the human cyclin A1 promoter and induces cyclin A1 gene expression Blood. ,vol. 94, pp. 4255- 4262 ,(1999) , 10.1182/BLOOD.V94.12.4255
J Miyauchi, CA Kelleher, C Wang, S Minkin, EA McCulloch, Growth factors influence the sensitivity of leukemic stem cells to cytosine arabinoside in culture. Blood. ,vol. 73, pp. 1272- 1278 ,(1989) , 10.1182/BLOOD.V73.5.1272.1272
Dong Liu, Martin M. Matzuk, Weng Kong Sung, Qiuxia Guo, Pei Wang, Debra J. Wolgemuth., Cyclin A1 is required for meiosis in the male mouse Nature Genetics. ,vol. 20, pp. 377- 380 ,(1998) , 10.1038/3855
Morosetti R, Koeffler Hp, Yang R, Characterization of a Second Human Cyclin A That Is Highly Expressed in Testis and in Several Leukemic Cell Lines Cancer Research. ,vol. 57, pp. 913- 920 ,(1997)
David Grimwade, Helen Walker, Fiona Oliver, Keith Wheatley, Christine Harrison, Georgina Harrison, John Rees, Ian Hann, Richard Stevens, Alan Burnett, Anthony Goldstone, The Importance of Diagnostic Cytogenetics on Outcome in AML: Analysis of 1,612 Patients Entered Into the MRC AML 10 Trial Blood. ,vol. 92, pp. 2322- 2333 ,(1998) , 10.1182/BLOOD.V92.7.2322
M. Pagano, R. Pepperkok, F. Verde, W. Ansorge, G. Draetta, Cyclin A is required at two points in the human cell cycle. The EMBO Journal. ,vol. 11, pp. 961- 971 ,(1992) , 10.1002/J.1460-2075.1992.TB05135.X
Hiroatsu Iida, Masayuki Towatari, Mitsune Tanimoto, Yoshihisa Morishita, Yoshihisa Kodera, Hidehiko Saito, Overexpression of cyclin E in acute myelogenous leukemia Blood. ,vol. 90, pp. 3707- 3713 ,(1997) , 10.1182/BLOOD.V90.9.3707
L Shi, D G Bosc, D He, A H Greenberg, D W Litchfield, G Chen, Granzyme B induces apoptosis and cyclin A-associated cyclin-dependent kinase activity in all stages of the cell cycle. Journal of Immunology. ,vol. 157, pp. 2381- 2385 ,(1996)
H M Kantarjian, M J Keating, R S Walters, K B McCredie, E J Freireich, The characteristics and outcome of patients with late relapse acute myelogenous leukemia. Journal of Clinical Oncology. ,vol. 6, pp. 232- 238 ,(1988) , 10.1200/JCO.1988.6.2.232