The molecular organization of asymmetric lipid bilayers and lipid-peptide complexes

摘要: Abstract Oriented fatty acid bilayers with asymmetric distributions of lipid head group types, hydrocarbon chain lengths, and associated polypeptides have been analyzed by a combined use high resolution electron microscopy X-ray diffraction techniques. The exclusion fixatives, stains, embedding materials has made it possible to relate unequivocally microscopic images molecular composition. ultrastructure determined novel analysis in which one half the bilayer serves as structural reference for entire bilayer. Absolute density profiles at 7 A computed formed from long short length lipids either segregated opposite sides or mixed together both data indicate that two self organize specific paired configuration. Detailed poly- l -lysine shows although this hydrophilic peptide resides near region, its presence alters arrangement chains.