The postantibiotic effect of selected antibiotics on Staphylococcus aureus Newbould 305 from bovine intramammary infection.

摘要: Summary The postantibiotic effect (PAE) was determined for selected antibiotics against Staphylococcus aureus Newbould 305 originating in vivo from mastitic milk and compared with the PAE same S. strain cultured vitro. The measured at 2 4 times MIC 1 h of exposure. penicillin, pirlimycin, tilmicosin were reduced grown cephapirin increased vivo. Minimal on noted novobiocin. rifampicin extended beyond limits test parameters (> 180 min) all antibiotic concentrations, media, exposure tested, except when to 60 min an may be important consideration determining therapy intervals concentrations treatment bovine mastitis.