Workshop on the qualitative and quantitative comparability of human and animal developmental neurotoxicity, Work Group IV report: triggers for developmental neurotoxicity testing.

摘要: Abstract A Work Group was formed to evaluate the criteria considered important in determining when require developmental neurotoxicity testing animal studies (i.e., triggers for testing). The primary objective of determine whether there is sufficient scientific evidence support identified by Environmental Protection Agency and use structure activity relationships (SAR) trigger automatic certain classes chemicals. weight (WOE) approach recommended order assist which agents should undergo what level testing. Evaluation biological effects, length duration exposure, quality quantity data available on an agent be used WOE approach. Agents that are teratogenic central nervous system (CNS) were highest priority testing, especially if potential a high degree exposure. Neuropathic neuroactive compounds, chemicals with hormone-like activity, toxicants (with effects other than structural abnormalities CNS) also likely candidates such Although reluctant recommend based solely SAR or chemical class, recognized importance considering along toxicity data, pharmacokinetic human exposure making final requirements recommendations further advised more (e.g., standard toxicity, reproductive adult neurotoxicity) developed need little no present environment work place at exposures approaching toxic levels, widespread likely.