Bromate: concern for developmental neurotoxicity?

摘要: The use of ozonation in the purification drinking water can lead to formation bromate. current regulatory challenges for bromate contamination include need assess potential human health risks. One risk concern is developmental neurotoxicity. Currently, a neurotoxicity study bromate, based on weight evidence, uncertain. Bromate induces adults at high acute exposures and produces hearing loss structural damage cochlea humans rodents. However, there wide margin exposure these studies compared environmental levels supplies. Data effects thyroid hormone not consistent endocrine disruption likely causative factor tumor formation. There no evidence that caused central nervous system malformations, brain changes studies, nor are any known structure-activity relationships other neurotoxicants. A prudent approach reduce uncertainty should determinations whether ototoxicity occurs with extended duration, low concentration exposures. These would provide invaluable data weight-of-evidence used determine necessity