Persistence of antibodies in children after intradermal or intramuscular administration of preexposure primary and booster immunizations with purified Vero cell rabies vaccine

摘要: Background. The use of intradermal (id) injections purified Vero cell rabies vaccine (PVRV) for preexposure prophylaxis has not been well-established. We studied the safety and immunogenicity id intramuscular (im) PVRV primary booster immunizations. Methods. One two regimens comprising three doses either 0.1 ml or 0.5 im administered during 28 days was assigned at random to 190 school children. dose given 1 year later im, according their initial randomization group. Serologic results were available from 155 (82%) children after immunization 118 (62%) 2 years booster. Results. Although vaccinated had significantly lower rabies-neutralizing antibody titers as well than (P < 0.001 all time points), there no significant differences in percentages with adequate (≥0.15 IU/ml) between groups both Mild local reactions more frequent vaccination. moderate systemic infrequent similar vaccinations. Fever headache reported by ≤6%. different those post-primary immunization. Conclusions. Purified appears be safe immunogenic An regimen should useful especially rabies-endemic countries low per capita income.