Inhibition of progression of PanIN through antagonizing EGFR
作者： Xiaojun He , Hui Zhang , Mei Xiao , Yalin Kong , Wenbing Li
DOI: 10.1007/S13277-014-2953-2
关键词:
摘要: Pancreatic ductal adenocarcinoma (PDAC) is an extremely malignant tumor with high lethality in humans. intraepithelial neoplasia (PanIN) the predominant precancerous lesion for PDAC. Although PanIN frequently detected normal and inflamed pancreas, only a few of eventually progress into Thus, inhibition PanIN-to-PDAC conversion critical preventing occurrence Here, we evaluated effect epidermal growth factor receptor (EGFR) signaling on progression low-grade high-grade PDAC established mouse model (Ptf1a-Cre; K-rasG12D). We found that intraductal infusion EGFR inhibitors at 12 weeks age, which induced sustained significantly decreased incidence these mice 24 age. our study suggests may prevent development
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