A comparison of the effects of skeletal muscle injury and somatic afferent nerve stimulation on the response to hemorrhage in anesthetized pigs.

摘要: The effect of skeletal muscle injury (SMI) on cardiovascular and O2 transport responses to hemorrhage (HS) were examined in anesthetized pigs. Bilateral hindlimb was injured 75 minutes before HS started at a rate 0.75 mL/min.kg until total 30 mL/kg (40% estimated blood volume) had been removed. reductions cardiac index (CI), left ventricular stroke work, oxygen delivery (Do2) the increase plasma lactate concentration following exacerbated by SMI such that although consumption maintained after it fell + HS. deleterious response greater than recorded previously somatic brachial nerve stimulation (BNS). Thus, order achieve given reduction CI Do2 or rise Shock Index (heart divided systolic pressure) approximately 3, loss 40% needed HS; this reduced 36% addition BNS, whereas only 29% when introduced. mechanism is unclear change distribution regional flow critical may be implicated.