Phosphorylation and Regulation of Raf by Akt (Protein Kinase B)

作者: S. Zimmermann

DOI: 10.1126/SCIENCE.286.5445.1741

关键词:

摘要: Activation of the protein kinase Raf can lead to opposing cellular responses such as proliferation, growth arrest, apoptosis, or differentiation. Akt (protein kinase B), a member of …

参考文章(23)
Asim Khwaja, Akt is more than just a Bad kinase Nature. ,vol. 401, pp. 33- 34 ,(1999) , 10.1038/43354
R. Marais, Y. Light, H.F. Paterson, C.J. Marshall, Ras recruits Raf‐1 to the plasma membrane for activation by tyrosine phosphorylation. The EMBO Journal. ,vol. 14, pp. 3136- 3145 ,(1995) , 10.1002/J.1460-2075.1995.TB07316.X
Geert J. P. L. Kops, Nancy D. de Ruiter, Alida M. M. De Vries-Smits, David R. Powell, Johannes L. Bos, Boudewijn M. Th. Burgering, Direct control of the Forkhead transcription factor AFX by protein kinase B Nature. ,vol. 398, pp. 630- 634 ,(1999) , 10.1038/19328
D. R. Alessi, M. Andjelkovic, B. Caudwell, P. Cron, N. Morrice, P. Cohen, B. A. Hemmings, Mechanism of activation of protein kinase B by insulin and IGF-1. The EMBO Journal. ,vol. 15, pp. 6541- 6551 ,(1996) , 10.1002/J.1460-2075.1996.TB01045.X
P. Beimling, M. Niehof, G. Radziwill, K. Moelling, The aminoterminus of c-Raf-1 binds a protein kinase phosphorylating Ser259. Biochemical and Biophysical Research Communications. ,vol. 204, pp. 841- 848 ,(1994) , 10.1006/BBRC.1994.2536
Walter Kolch, Gisela Heidecker, Georg Kochs, Richard Hummel, Haleh Vahidi, Harald Mischak, Günter Finkenzeller, Dieter Marmé, Ulf R. Rapp, Protein kinase Cα activates RAF-1 by direct phosphorylation Nature. ,vol. 364, pp. 249- 252 ,(1993) , 10.1038/364249A0
Pablo Rodriguez-Viciana, Patricia H Warne, Asim Khwaja, Barbara M Marte, Darryl Pappin, Pamela Das, Michael D Waterfield, Anne Ridley, Julian Downward, Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras Cell. ,vol. 89, pp. 457- 467 ,(1997) , 10.1016/S0092-8674(00)80226-3
Aimee D. Kohn, Scott A. Summers, Morris J. Birnbaum, Richard A. Roth, Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation Journal of Biological Chemistry. ,vol. 271, pp. 31372- 31378 ,(1996) , 10.1074/JBC.271.49.31372
B.-H. Jiang, M. Aoki, J. Z. Zheng, J. Li, P. K. Vogt, MYOGENIC SIGNALING OF PHOSPHATIDYLINOSITOL 3-KINASE REQUIRES THE SERINE-THREONINE KINASE AKT/PROTEIN KINASE B Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 2077- 2081 ,(1999) , 10.1073/PNAS.96.5.2077